Research Article   
IDENTIFICATION AND ANALYSIS OF CRITICAL GENES IN EARLY-ONSET ALZHEIMER'S DISEASE AND RELATED UNDERLYING DISEASES
Author(s): Maryam Zangi Darestani, Zahra Ziaastani, Mehdi Abbasnejad, Behjat Kalantari-Khandani and Ali Kazemipour* Background: Alzheimer's Disease (AD) is a neurodegenerative and multifactorial disorder. The investigation of the key genes and metabolic pathways is important to understanding the mechanism of AD. This study aimed to analyze the gene network and biological pathways of AD using bioinformatics approaches. Materials and methods: AD genes were identified and a gene network was constructed using the STRING. Network analysis was performed to identify functional modules and key genes related to AD by Cytoscape and investigate their gene ontology using the g: Profiler. Results: By network clustering, five functional modules were identified, which play an important role in amyloid-beta formation, protein metabolic process, and response to organic substance. APOE, TREM2, SORL1, BIN1, PICALM, ABCA7, CD2AP, CD33, MS4A6A, .. Read More» DOI: 10.54615/2231-7805.47395

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