Perspective   
HUMAN PAPILLOMAVIRUS AND ITS POTENTIAL IMPACT ON ALZHEIMER’S AND PARKINSON’S DISEASES
Author(s): Haifeng Ding* Background: Neurodegenerative diseases such as Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) have been widely studied, with emerging evidence suggesting that viral infections may play a role in their onset and progression. This study utilizes a two-sample Mendelian Randomization (MR) approach to assess potential causal links between Human Papillomavirus (HPV) infection and these neurodegenerative diseases. Methods: A two-sample MR analysis was conducted using Instrumental Variables (IVs) derived from Genome-Wide Association Studies (GWAS) data. SNPs associated with HPV16 and HPV18 E7 proteins, as well as HPV seropositivity, were analyzed in relation to AD and PD risk. Sensitivity analyses, including Cochran’s Q-test and MR-Egger intercept, were performed to evaluate robustness and potential pleiotropy. .. Read More» DOI: 10.54615/2231-7805.47397

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