Reach Us +442837180055
mental health, psychiatry and mental health, journals on mental health, mental health journals, journals mental health
journals for mental health, best journals for mental health, mental health journals uk, journals on psychiatry
journals of psychiatry, psychiatry journals, asean, journal
Google Scholar citation report
Citations : 2789

ASEAN Journal of Psychiatry received 2789 citations as per google scholar report

ASEAN Journal of Psychiatry peer review process verified at publons
Journal Name ASEAN Journal of Psychiatry (MyCite Report)  
Total Publications 32
Total Citations 16
Total Non-self Citations 12
Yearly Impact Factor 0.053
5-Year Impact Factor 0.104
Immediacy Index 0.000
Cited Half-life 2.7
H-index 3
Social Sciences Medical & Health Sciences
Q3 Q2


The Antipsychotic Ziprasidone has Cito-Genotoxic and Pro-Inflammatory Effects Influenced by VAL16ALA-SOD2 Gene Polymorphism

Author(s): Ivana Beatrice Mânica da Cruz, Thiago Duarte, Fernanda Barbisan, Danieli M. Pillar, Verônica Farina Azzolin, Marta Maria Medeiros Frescura Duarte

Objectives: In immune cells, especially macrophages some oxidant molecules present a key role on inflammatory response trigger by pathogens and non-pathogens substances. For this reason, basal genetic superoxide-hydrogen peroxide (S-HP) imbalance as caused by Val16Ala-SOD2 single nucleotide polymorphism (SNP) could has some influence on side effects induced by pharmacological drugs. This could be de case of Ziprasidone (ZIP), a second-generation antipsychotic (SGA) used to treat some psychiatric and neurodegenerative diseases that seems to act on oxidative-inflammatory metabolism. To test this hypothesis, an in vitro study using human peripheral blood mononuclear cells (PBMCs) carrying different Val16Ala-SOD2 genotypes was performed. In standardized 72h cell cultures, the effect of ZIP exposure at plasmatic therapeutic concentration in oxidative (including level of DNA oxidation quantified by 8-deoxiguanosine) and inflammatory markers were analysed. Results showed that AA-PBMCs that have basal higher HP levels presented cito-genotoxic effect when ZIP-exposed, whereas VV-PBMCs presented higher levels of proinflammatory cytokines. The whole of results indicated some pharmacogenomic action of Val16Ala-SOD2 SNP despite in vitro methodological constrains. A


scan code
Get the App