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SOCIETIES:
JOURNAL COVER:
Google scholar citation report
Citations : 874

ASEAN Journal of Psychiatry received 874 citations as per google scholar report

ASEAN Journal of Psychiatry peer review process verified at publons
IMPACT FACTOR:
Journal Name ASEAN Journal of Psychiatry (MyCite Report)  
Total Publications 32
Total Citations 16
Total Non-self Citations 12
Yearly Impact Factor 0.053
5-Year Impact Factor 0.104
Immediacy Index 0.000
Cited Half-life 2.7
H-index 3
Quartile
Social Sciences Medical & Health Sciences
Q3 Q2

Abstract

The Antipsychotic Ziprasidone has Cito-Genotoxic and Pro-Inflammatory Effects Influenced by VAL16ALA-SOD2 Gene Polymorphism

Author(s): Ivana Beatrice Mânica da Cruz, Thiago Duarte, Fernanda Barbisan, Danieli M. Pillar, Verônica Farina Azzolin, Marta Maria Medeiros Frescura Duarte

Objectives: In immune cells, especially macrophages some oxidant molecules present a key role on inflammatory response trigger by pathogens and non-pathogens substances. For this reason, basal genetic superoxide-hydrogen peroxide (S-HP) imbalance as caused by Val16Ala-SOD2 single nucleotide polymorphism (SNP) could has some influence on side effects induced by pharmacological drugs. This could be de case of Ziprasidone (ZIP), a second-generation antipsychotic (SGA) used to treat some psychiatric and neurodegenerative diseases that seems to act on oxidative-inflammatory metabolism. To test this hypothesis, an in vitro study using human peripheral blood mononuclear cells (PBMCs) carrying different Val16Ala-SOD2 genotypes was performed. In standardized 72h cell cultures, the effect of ZIP exposure at plasmatic therapeutic concentration in oxidative (including level of DNA oxidation quantified by 8-deoxiguanosine) and inflammatory markers were analysed. Results showed that AA-PBMCs that have basal higher HP levels presented cito-genotoxic effect when ZIP-exposed, whereas VV-PBMCs presented higher levels of proinflammatory cytokines. The whole of results indicated some pharmacogenomic action of Val16Ala-SOD2 SNP despite in vitro methodological constrains. A


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