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Google Scholar citation report
Citations : 934

ASEAN Journal of Psychiatry received 934 citations as per google scholar report

ASEAN Journal of Psychiatry peer review process verified at publons
Journal Name ASEAN Journal of Psychiatry (MyCite Report)  
Total Publications 32
Total Citations 16
Total Non-self Citations 12
Yearly Impact Factor 0.053
5-Year Impact Factor 0.104
Immediacy Index 0.000
Cited Half-life 2.7
H-index 3
Social Sciences Medical & Health Sciences
Q3 Q2


Role of Calcium calmodulin-dependent protein kinase II (CaMKII) in synapse formation and synaptic Transmission between Lymnaea neurons.

Author(s): Atiq Hassan, Nazim Nasir, Mohammad Suhail khan, Izhar Husain

Networks of synaptically connected neurons underlie all brain functions. Various cell-cell signaling and extrinsic molecules influence synapse assembly at the synaptic site. Calcium ions play a significant role in signal transduction pathways that control various neuronal functions. Multifunctional Ca2+/calmodulin-dependent protein kinase II (CaMK II) is an important mediator of calcium signaling in neurons, it plays an essential role in controlling synaptic strength and plasticity, and it is highly expressed in the cytosol of developing neurons, especially in presynaptic neurons. However, the precise role of CaMKII in synapse formation and synaptic transmission has not yet been determined. We hypothesized that CaMKII activity could be necessary for synapse formation and synaptic transmission. To test whether CaMKII activity is required for the synapse formation and synaptic transmission, the identified neurons visceral dorsal 4 (VD4 – presynaptic) and its postsynaptic partner left pedal dorsal 1 (LPeD1) from the freshwater snail Lymnaea stagnalis were paired in soma-soma configuration in cell culture. The soma-soma paired cells recapitulated their excitatory connections in vitro. To test the possible role of CaMKII in synapse formation and synaptic transmission, the in vitro paired neurons were exposed to a CaMKII-specific inhibitor KN-93 and its inactive analog KN-92. The incidence of synapse formation and efficacy of synaptic transmission was tested electrophysiologically. In this study, we have demonstrated that paired neurons cultured in the presence of CaMKII inhibitor KN-93 do not affect the incidence of synapse formation; however, it reduces synaptic transmission. In contrast, paired neurons exposure to KN-92 did not affect the synapse formation and synaptic transmission at synapses between identified neurons. Taken together, CaMKII activity was not required for normal synapse formation; nevertheless, it plays an essential role in synaptic transmission between the soma-soma-paired Lymnaea neurons. 


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