Open Journal Systems

Thrombocytopenia With Valproate And Clozapine Combination Therapy

Charmaine Tang, Jimmy Lee, Jayaraman Hariram

Abstract


Objective:
The occurrence of thrombocytopenia with valproate and clozapine combination therapy has not been noted in the literature. This case report highlights thrombocytopenia as a potential outcome of drug-drug interaction between valproate and clozapine, and serves to remind practitioners that regular monitoring of platelet counts is necessary in such combination therapy.

Method:
We report on a patient on valproate therapy who developed thrombocytopenia when clozapine was added to her treatment regime.

Results:
Thrombocytopenia resolved 1 week after valproate was tailed off and the patient was placed on clozapine monotherapy.

x
Message